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Pyridazine Derivatives as Novel Acyl-CoA:Cholesterol Acyltransferase (ACAT) Inhibitors

โœ Scribed by Arianna Gelain

Book ID
101972783
Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

๐Ÿ“œ SIMILAR VOLUMES

Pyridazine derivatives as novel acyl-coa
Pyridazine derivatives as novel acyl-coa:cholesterol acyltransferase (acat) inhibitors
โœ Arianna Gelain ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 96 KB

Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor

Acyl CoA:cholesterol acyltransferase (AC
Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing two heterocyclic head groups
โœ Richard G. Wilde; Jeffrey T. Billheimer ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 232 KB

A series of compounds bearing two heterocyclic substituents were prepared, and evaluated for inhibition of aeyl-CoA:cholesterol acyltransferase (ACAT). The heterocyclic groups were chosen for dual potency against hepatic and macrophage cell ACAT. Several examples of ACAT-balanced compounds were disc