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Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing two heterocyclic head groups

โœ Scribed by Richard G. Wilde; Jeffrey T. Billheimer

Book ID
103982817
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
232 KB
Volume
5
Category
Article
ISSN
0960-894X

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โœฆ Synopsis

A series of compounds bearing two heterocyclic substituents were prepared, and evaluated for inhibition of aeyl-CoA:cholesterol acyltransferase (ACAT). The heterocyclic groups were chosen for dual potency against hepatic and macrophage cell ACAT. Several examples of ACAT-balanced compounds were discovered, and the results of this study, including synthesis, are presented.

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