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Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: ureas bearing heterocyclic groups bioisosteric for an imidazole

โœ Scribed by Richard G. Wilde; Jeffrey T. Billheimer; Sandra J. Germain; Peter J. Gillies; C.Anne Higley; Hollis S. Kezar III; Thomas P. Maduskuie; Edward S. Shimshick; Ruth R. Wexler


Book ID
103982816
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
312 KB
Volume
5
Category
Article
ISSN
0960-894X

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Acyl CoA:cholesterol acyltransferase (AC
โœ Richard G. Wilde; Jeffrey T. Billheimer ๐Ÿ“‚ Article ๐Ÿ“… 1995 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 232 KB

A series of compounds bearing two heterocyclic substituents were prepared, and evaluated for inhibition of aeyl-CoA:cholesterol acyltransferase (ACAT). The heterocyclic groups were chosen for dual potency against hepatic and macrophage cell ACAT. Several examples of ACAT-balanced compounds were disc