Acyl CoA:cholesterol acyltransferase (AC
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Richard G. Wilde; Jeffrey T. Billheimer
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Article
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1995
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Elsevier Science
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English
โ 232 KB
A series of compounds bearing two heterocyclic substituents were prepared, and evaluated for inhibition of aeyl-CoA:cholesterol acyltransferase (ACAT). The heterocyclic groups were chosen for dual potency against hepatic and macrophage cell ACAT. Several examples of ACAT-balanced compounds were disc