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Acyl CoA:cholesterol acyltransferase (ACAT) inhibitors: heterocyclic bioisosteres for the urea group in DuP 128

✍ Scribed by Richard G. Wilde; John D. Klaczkiewicz; Jeffrey T. Billheimer; Ruth R. Wexler; Peter J. Gillies

Book ID: 103982818
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 242 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00003-c

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A series of compounds bearing two heterocyclic substituents were prepared, and evaluated for inhibition of aeyl-CoA:cholesterol acyltransferase (ACAT). The heterocyclic groups were chosen for dual potency against hepatic and macrophage cell ACAT. Several examples of ACAT-balanced compounds were disc