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Novel aryloxyalkylthioimidazoles as inhibitors of acyl-CoA: cholesterol-O-acyltransferase

โœ Scribed by M Bani; R Bormetti; W Ceccarelli; R Fiocchi; M Gobetti; M Lombroso; S Magnetti; V Olgiati; M Palladino; M Villa; E Vanotti

Book ID
103630031
Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
787 KB
Volume
30
Category
Article
ISSN
0223-5234

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โœ Arianna Gelain ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› Journal of Heterocyclic Chemistry ๐ŸŒ English โš– 96 KB

Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor