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Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors

โœ Scribed by Tae-Sook Jeong; Kyung Soon Kim; So-Jin An; Kyung-Hyun Cho; Sangku Lee; Woo Song Lee


Book ID
108073306
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
241 KB
Volume
14
Category
Article
ISSN
0960-894X

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Acyl-CoA:cholesterol acyltransferase (E.C.2.3.1.26, ACAT) is a microsomial enzyme that catalyses the formation of cholesteryl esters by acylation of cholesterol with long chain fatty acylCoA [1]. ACAT plays important roles in cellular homeostasis and in the early stages of atherosclerosis. Therefor