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ChemInform Abstract: Novel Tetrahydroisoquinoline Derivatives with Inhibitory Activities Against Acyl-CoA: Cholesterol Acyltransferase and Lipid Peroxidation.

✍ Scribed by Masaru Ohta; Kenji Takahashi; Masayasu Kasai; Yoshimichi Shoji; Kazuyoshi Kunishiro; Tomohiro Miike; Mamoru Kanda; Chisato Mukai; Hiroaki Shirahase

Publisher: John Wiley and Sons
Year: 2010
Weight: 23 KB
Volume: 42
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.201101208

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✦ Synopsis

Abstract

Among the title derivatives, compound (I) exhibits 16‐fold stronger anti‐foam cell formation activity, 3‐fold stronger hepatic ACAT inhibitory activity, similar LDL oxidative activity and 2‐fold more potent protective activity against macrophage cell death compared to the known ACAT inhibitor Pactimibe.

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