## Abstract Among the title derivatives, compound (I) exhibits 16โfold stronger antiโfoam cell formation activity, 3โfold stronger hepatic ACAT inhibitory activity, similar LDL oxidative activity and 2โfold more potent protective activity against macrophage cell death compared to the known ACAT inh
ChemInform Abstract: Bioavailable Acyl-CoA: Cholesterol Acyltransferase Inhibitor with Anti-peroxidative Activity: Synthesis and Biological Activity of Novel Indolinyl Amide and Urea Derivatives.
โ Scribed by Shoji Kamiya; Hiroaki Shirahase; Akihisa Yoshimi; Shohei Nakamura; Mamoru Kanda; Hiroshi Matsui; Masayasu Kasai; Kenji Takahashi; Kazuyoshi Kurahashi
- Publisher
- John Wiley and Sons
- Year
- 2000
- Weight
- 29 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0931-7597
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โฆ Synopsis
Abstract
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a โFull Textโ option. The original article is trackable via the โReferencesโ option.
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## Abstract A series of novel Nโ(substituted hetaryl)โ4โarylโ4โoxobutanamides are designed, synthesis and evaluated for their activity against DGATโ1 enzyme.