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Studies with the neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and several of its analogs

โœ Scribed by Richard E. Heikkila; Stephen K. Youngster; Diana U. Panek; Andrew Giovanni; Patricia K. Sonsalla


Book ID
107937583
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
508 KB
Volume
49
Category
Article
ISSN
0300-483X

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๐Ÿ“œ SIMILAR VOLUMES


Conversion of 1-methyl-4-phenyl-1,2,3,6-
โœ Wieslaw Gessner; Arnold Brossi; Rong-Sen Shen; Richard R. Fritz; Creed W. Abell ๐Ÿ“‚ Article ๐Ÿ“… 1984 ๐Ÿ› John Wiley and Sons ๐ŸŒ German โš– 383 KB

## Abstract Monoamine oxidase B metabolizes 1โ€methylโ€4โ€phenylโ€1,2,3,6โ€tetrahydropyridine (MPTP; **1**) first to 1โ€methylโ€4โ€phenylโ€2,3โ€dihydropyridinium salt (MPDP^+^; **5**), and then to 1โ€methylโ€4โ€phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5โ€methyl analog **6** wa