Mutagenicity of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and its metabolites
✍ Scribed by John R. Cashman
- Book ID
- 107937518
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 546 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0300-483X
No coin nor oath required. For personal study only.
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## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa
## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP