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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and free radicals in vitro

✍ Scribed by Zvani L. Rossetti; Antonello Soroiut; Dale E. Sharp; Maria Hadjiconstantinou; Norton H. Neff


Book ID
115780647
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
229 KB
Volume
37
Category
Article
ISSN
0006-2952

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP