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Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations

✍ Scribed by John K. Baker; Ronald F. Borne; W. Marvin Davis; I.Wade Waters


Book ID
115757487
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
369 KB
Volume
125
Category
Article
ISSN
0006-291X

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP