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Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by bovine brain microvessel endothelial cells

✍ Scribed by Gerhard K.E. Scriba; Ronald T. Borchardt


Book ID
115799710
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
315 KB
Volume
501
Category
Article
ISSN
0006-8993

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP