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New amphibian models for the study of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

✍ Scribed by A. Barbeau; L. Dallaire; N.T. Buu; F. Veilleux; H. Boyer; L.E. de Lanney; I. Irwin; E.B. Langston; J.W. Langston

Book ID: 118341292
Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 565 KB
Volume: 36
Category: Article
ISSN: 0024-3205
DOI: 10.1016/0024-3205(85)90498-9

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## Abstract In 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) models of Parkinson's disease (PD), dopaminergic (DA) neurons have been shown to die by apoptosis. Moreover, recent postmortem and in vitro results have indicated that apoptotic cell death induced by 1‐methyl‐4‐phenylpyridinium (MPP