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V. Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

โœ Scribed by N. Castagnoli Jr.; K. Chiba; A.J. Trevor


Book ID
118340863
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
275 KB
Volume
36
Category
Article
ISSN
0024-3205

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Primary cultures of mouse astrocytes were treated with both the monoamine oxidase (MAO) A inhibitor, clorgyline, and the MA0 B inhibitor, deprenyl, prior to the addition of the neurotoxicant 1 -methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP). Production of the 1-methyl-4-phenylpyridinium (MPP+) to