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Synthesis and toxicity toward nigrostriatal dopamine neurons of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) analogs

✍ Scribed by Fries, David S.; De Vries, Jan; Hazelhoff, Bernard; Horn, Alan S.

Book ID: 120418692
Publisher: American Chemical Society
Year: 1986
Tongue: English
Weight: 560 KB
Volume: 29
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm00153a019

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## Abstract Monoamine oxidase B metabolizes 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP; **1**) first to 1‐methyl‐4‐phenyl‐2,3‐dihydropyridinium salt (MPDP^+^; **5**), and then to 1‐methyl‐4‐phenylphridinium salt (MPP^+^; **7**). Chemical synthesis of MPDP^+^ and its 5‐methyl analog **6** wa