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Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 25. Synthesis of new imidazolyl and pyrazolyl derivatives of thiophene as inhibitors of nitric oxide synthase

โœ Scribed by Thomas Erker; Maria E. Galanski; Markus Galanski

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
60 KB
Volume
39
Category
Article
ISSN
0022-152X

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โœฆ Synopsis

Abstract

Some novel imidazolyl and pyrazolyl thiophene derivatives were synthesized. Different substituted Nโ€containing heterocycles were chosen with the aim of enhancing the activity or selectivity of the products towards inhibition of one of the three isoforms of nitric oxide synthase. One series of substances was prepared by substitution reactions of 3โ€bromoโ€2โ€nitrothiophene with various heterocycles. In the other series introduction of a second heterocyclic substituent to pyrazolylthiophene compounds was attempted.

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