Studies on the chemistry of thienoannelated o,n- and s,n-containing heterocycles. 16. Synthesis of some thieno[1,4]thiazine derivatives with potential calcium antagonistic activity
β Scribed by Thomas Erker
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1998
- Tongue
- English
- Weight
- 414 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-152X
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β¦ Synopsis
Abstract
Substituted thieno[1,4]thiazine derivatives have been synthesized. They are thienoanalogues of compound 3 [2], a potent cerebral protectant and calcium antagonist. Research activities concentrate on the preparation of structurally modified compounds of 3 to minimize its undesirable symptoms.
π SIMILAR VOLUMES
## Abstract A facile synthesis of the imidazo[1,5β__d__]thieno[2,3β__b__][1,4]thiazine ring system is described. Reaction of 6βbenzylβ2,3βdihydroβ1__H__βthieno[2,3β__b__][1,4]thiazineβ2βone (**1**) with potassium __tert__βbutoxide and diethylchlorophosphate gave intermediate **2** which resulted in
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
## Abstract A new series of substituted thieno[1,4]thiazines with an urea moiety has been designed. The synthesis and results of replacement of the quinoline and indoline moieties of lead structure **1** are described. The key step in preparation was the substitution with 4βnitrophenyl chloroformat
## Abstract For Abstract see ChemInform Abstract in Full Text.