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Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 17. Preparation of 1H-thieno[2,3-b][1,4]thiazine-1-carboxarnides as smooth muscle relaxants

✍ Scribed by Maria E. Schreder; Thomas Erker

Publisher: Journal of Heterocyclic Chemistry
Year: 2000
Tongue: English
Weight: 373 KB
Volume: 37
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570370220

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✦ Synopsis

Abstract

A new series of substituted thieno[1,4]thiazines with an urea moiety has been designed. The synthesis and results of replacement of the quinoline and indoline moieties of lead structure 1 are described. The key step in preparation was the substitution with 4‐nitrophenyl chloroformate to obtain the required reactivity for substitution with diamines. Structural modifications of the amino side chain with the aim of finding tissue specific compounds were carried out. Pharmacological testings explored the presumed calcium‐channel‐antagonistic and potassium‐channel‐opening activities.

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