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Studies on the chemistry of thienoannelated O,N- and S,N-containing heterocycles. 24 [1]. Synthesis of imidazo[1,5-d]thieno[2,3-b][1,4]-thiazine derivatives as potential receptor ligands

✍ Scribed by Thomas Erker; Norbert Handler

Publisher: Journal of Heterocyclic Chemistry
Year: 2002
Tongue: English
Weight: 38 KB
Volume: 39
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.5570390407

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✦ Synopsis

Abstract

A facile synthesis of the imidazo[1,5‐d]thieno[2,3‐b][1,4]thiazine ring system is described. Reaction of 6‐benzyl‐2,3‐dihydro‐1__H__‐thieno[2,3‐b][1,4]thiazine‐2‐one (1) with potassium tert‐butoxide and diethylchlorophosphate gave intermediate 2 which resulted in the disired ring system after adding the corresponding isocyanides and potassium tert‐butoxide.

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