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Studies on the chemistry of O,N- and S,N-containing heterocycles. 16. Investigations on the synthesis of new tricyclic β-lactams via [2+2]cycloaddition reaction

✍ Scribed by Susanne Pippich; Herbert Bartsch; Thomas Erker

Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
527 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Starting from methylthioimidates 1–8 a series of corresponding tricyclic β‐lactams was synthesized via [2+2]cycloaddition with ketenes generated in situ from substituted acetyl chlorides. Dependent on the bicyclic starting material and on the substituent of the corresponding acetyl chloride N‐acetyl derivatives were obtained as by‐ or sole products.

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