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Structures of phospholipase A2 inhibitors, ergophilones A and B

✍ Scribed by Satoshi Hyodo; Ken-ichi Fujita; Osamu Kasuya; Isamu Takahashi; Jun Uzawa; Hiroyuki Koshino


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
373 KB
Volume
51
Category
Article
ISSN
0040-4020

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The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm