ChemInform Abstract: Dicarboxylic Acid Inhibitors of Phospholipase A2.
β Scribed by D. M. SPRINGER; B.-Y. LUH; S. V. D'ANDREA; J. J. BRONSON; M. M. MANSURI; J. R. BURKE; K. R. GREGOR; P. L. STANLEY; K. M. TRAMPOSCH
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 28 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0931-7597
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Synthesis of Substituted Benzoyl Acrylic Acids as Potential Inhibitors of Phospholipase A 2 . -Acylation of long-chain alkylbenzenes with maleic anhydride derivatives under Friedel-Crafts conditions provides access to benzoylacrylic acids [cf. (III)/(IV), (VIII)], which are evaluated for their abili