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Identification of the B Subtype of γ-Phospholipase A2Inhibitor fromProtobothrops flavoviridisSerum and Molecular Evolution of Snake Serum Phospholipase A2Inhibitors

✍ Scribed by Shuhei So; Takahito Chijiwa; Naoki Ikeda; Ikuo Nobuhisa; Naoko Oda-Ueda; Shosaku Hattori; Motonori Ohno


Publisher
Springer
Year
2008
Tongue
English
Weight
625 KB
Volume
66
Category
Article
ISSN
0022-2844

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The X-ray structures of pancreatic bovine and porcine phospholipases A2 have been used along with interactive computer graphics to design conformationally rigid, novel compounds (1-meta-hydroxybenzyl-2-substituted acenaphthenes) directed at the active sites of these enzymes. In vitro testing confirm