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Structure—Activity Relationships of the Oxindole Growth Hormone Secretagogues.

✍ Scribed by Teruhisa Tokunaga; W. Ewan Hume; Jun Nagamine; Tetsuya Kawamura; Mutsuo Taiji; Ryu Nagata


Book ID
101977943
Publisher
John Wiley and Sons
Year
2005
Weight
17 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


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The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating