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The synthesis and activity of spiroindane growth hormone secretagogues

✍ Scribed by James R. Tata; Ravi P. Nargund; Marcia M. Murphy; David B.R. Johnston; Arthur A. Patchett; Kang Cheng; Liente Wei; Wanda W.-S. Chan; Bridget Butler; Thomas M. Jacks; Gerard Hickey; Roy Smith

Book ID: 104364888
Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 246 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00075-9

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✦ Synopsis

The synthesis and activities of a series of spiroindane growth hormone secretagogues is reported. Modification of the benzylic position of the spiroindane has resulted in a dramatic increase in potency resulting in subnanomolar peptidomimetic growth hormone secretagogues. In vivo data demonstrating the good oral activity of these analogs is reported.

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