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Analogs of the orally active growth hormone secretagogue L-162,752

✍ Scribed by Meng-Hsin Chen; Mark G. Steiner; Arthur A. Patchett; Kang Cheng; Liente Wei; Wanda W.-S. Chan; Bridget Butler; Thomas M. Jacks; Roy G. Smith


Book ID
108039055
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
255 KB
Volume
6
Category
Article
ISSN
0960-894X

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Synthesis of the orally active spiroindo
✍ Peter E. Maligres; Ioannis Houpis; Kai Rossen; Audrey Molina; Jess Sager; Veena πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 French βš– 706 KB

The preparation of the Merck Growth Hormone Secretagogue; MK-677 is described. A Fischer indole/reduction based strategy provides the novel spiroindoline nucleus of this potent compound. This optimized sequence necessitates the isolation of only one intermediate 10 and provides MK-677 in 48% overall