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Structure–activity relationship studies on tetralin carboxamide growth hormone secretagogue receptor antagonists

✍ Scribed by Hongyu Zhao; Zhili Xin; Jyoti R. Patel; Lissa T.J. Nelson; Bo Liu; Bruce G. Szczepankiewicz; Verlyn G. Schaefer; H. Douglas Falls; Wiweka Kaszubska; Christine A. Collins; Hing L. Sham; Gang Liu


Book ID
108073584
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
121 KB
Volume
15
Category
Article
ISSN
0960-894X

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Structure–activity relationship studies
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A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding