Structure–activity relationship studies
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Richard L. Elliott; Robert M. Oliver; Janet A. LaFlamme; Melissa L. Gillaspy; Ma
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Article
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2003
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Elsevier Science
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English
⚖ 142 KB
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding