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ChemInform Abstract: Indole Amide Derivatives: Synthesis, Structure—Activity Relationships, and Molecular Modeling Studies of a New Series of Histamine H1-Receptor Antagonists.

✍ Scribed by Sandra Battaglia; Enrico Boldrini; Federico Da Settimo; Giulio Dondio; Concettina La Motta; Anna Maria Marini; Giampaolo Primofiore

Publisher: John Wiley and Sons
Year: 2010
Weight: 31 KB
Volume: 30
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.199929124

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Synthesis and Histamine H1-Receptor Antagonist Activity of 4-( Diphenylmethyl)-1-piperazine Derivatives with a Terminal Heteroaryl or Cycloalkyl Amide Fragment. -The title compounds (I) have the highest biological activities and are as potent in vivo as cetirizine.