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Stereospecific Synthesis and Biological Evaluation of Farnesyl Diphosphate Isomers

✍ Scribed by Shao, Ying; Eummer, Jeffrey T.; Gibbs, Richard A.

Book ID
120928243
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
64 KB
Volume
1
Category
Article
ISSN
1523-7060

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ChemInform Abstract: Stereospecific Synt
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Stereospecific Synthesis and Biological Evaluation of Farnesyl Diphosphate Isomers. -The diphosphates (Ia) and (II) are found to be very potent substrates for mammalian protein-farnesyl transferase. The isomer (Ib) is a submicromolar inhibitor of the transferase. -(SHAO, YING; EUMMER,

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Prenyl, geranyl, and farnesyl derivatives containing nonionic surrogates for the diphosphate moiety, including disulfones 4-6 and 7-9, methylene disulfonamides 10-12, and carbamyl sulfamides 13-15, have been synthesized and evaluated biologically in an effort to find suitable nonlabile, neutral inhi

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