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Synthesis and Biochemical Evaluation of 3,7-Disubstituted Farnesyl Diphosphate Analogues

✍ Scribed by Rawat, Diwan S.; Krzysiak, Amanda J.; Gibbs, Richard A.


Book ID
124154810
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
184 KB
Volume
73
Category
Article
ISSN
0022-3263

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Synthesis and antimicrobial evaluation o
✍ Ian J.S. Fairlamb; Julia M. Dickinson; Rachael O’Connor; Louis H. Cohen; Christa πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 324 KB

The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a omega-phenyl