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Synthesis and Evaluation of Chlorinated Substrate Analogues for Farnesyl Diphosphate Synthase

✍ Scribed by Heaps, Nicole A.; Poulter, C. Dale


Book ID
118028717
Publisher
American Chemical Society
Year
2011
Tongue
English
Weight
943 KB
Volume
76
Category
Article
ISSN
0022-3263

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Synthesis and antimicrobial evaluation o
✍ Ian J.S. Fairlamb; Julia M. Dickinson; Rachael O’Connor; Louis H. Cohen; Christa πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 English βš– 324 KB

The synthesis and first antimicrobial evaluation of farnesyl diphosphate mimetics are described. Several analogues (10, 12, 13, and 20) are inhibitors of Candida albicans, Shizosaccharomyces pombe, and Saccharomyces cerevisiae. The activities of analogues 10, 12, and 13, which contain a omega-phenyl