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Stereoselective synthesis of β2-amino acids by Michael addition of diorgano zinc reagents to nitro acrylates

✍ Scribed by Uwe Eilitz; Frank Leßmann; Oliver Seidelmann; Volkmar Wendisch


Book ID
104359581
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
75 KB
Volume
14
Category
Article
ISSN
0957-4166

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Asymmetric synthesis of β-amino acid der
✍ Ian T. Barnish; Martin Corless; Peter J. Dunn; David Ellis; Paul.W. Finn; J.Davi 📂 Article 📅 1993 🏛 Elsevier Science 🌐 French ⚖ 254 KB

The addition of lithium enolates to chiral aminomethylacrylates 7 and 8 proceeded with excellent diastereodifferentiation (up to 98% de) and provided an expeditious synthesis of homochiral fi-aminomethylglutarates 9 and 10, on a scale of up-to 5OOg. The a&lates 7 and%, and their antipodes, should be