Stereoselective synthesis of β2-amino acids by Michael addition of diorgano zinc reagents to nitro acrylates
✍ Scribed by Uwe Eilitz; Frank Leßmann; Oliver Seidelmann; Volkmar Wendisch
- Book ID
- 104359581
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 75 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0957-4166
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📜 SIMILAR VOLUMES
The copper(I)-catalysed Michael addition of trimethyl aluminium to nitro acrylates yields 2-methyl-3-nitro propionic acid esters on a 200 g scale with enantiomeric excesses up to 92%.
## Abstract For Abstract see ChemInform Abstract in Full Text.
The addition of lithium enolates to chiral aminomethylacrylates 7 and 8 proceeded with excellent diastereodifferentiation (up to 98% de) and provided an expeditious synthesis of homochiral fi-aminomethylglutarates 9 and 10, on a scale of up-to 5OOg. The a&lates 7 and%, and their antipodes, should be