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Stereoselective Synthesis of β2-Amino Acids by Michael Addition of Diorgano Zinc Reagents to Nitro Acrylates.

✍ Scribed by Uwe Eilitz; Frank Lessmann; Oliver Seidelmann; Volkmar Wendisch


Publisher
John Wiley and Sons
Year
2003
Weight
167 KB
Volume
34
Category
Article
ISSN
0931-7597

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## Michael addition / Nitro alkenes / C-O bond cleavage The first intermolecular asymmetric oxa Michael additions cleavage of the auxiliary occurred without epimerisation (69-99%) using Na/NH 3 . The Boc-protected 2-amino alcohols with removable chirality information within the hydroxide source ar