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Stereoselective Access to β- C -Glycosamines by Nitro-Michael Addition of Organolithium Reagents

✍ Scribed by Delaunay, Thierry; Poisson, Thomas; Jubault, Philippe; Pannecoucke, Xavier


Book ID
121846983
Publisher
John Wiley and Sons
Year
2014
Tongue
English
Weight
478 KB
Volume
2014
Category
Article
ISSN
1434-193X

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Enantioselective addition of organolithi
✍ Pher G. Andersson; Fredrik Johansson; David Tanner 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 888 KB

The C2-symmetric bis(aziridine) ligands 1 -5 have been screened in the enantioselective addition of organolithium reagents to imines. Ligand 1 (used in stoichiometric amounts) was found to be superior in terms of chemical yield and enantioselectivity, the best result being 90\*70 yield and 89% e.e.