The synthesis of a new 3-hydroxy-3-methylglutaryl coenzyme A reduc-----tase inhibitor starting from 4,4' -difluorobenzophenone is described. Mevinolin 1 and its congeners are potent inhibitors of 3-hydroxy-3-methyl-
Stereoselective synthesis of HR 780 a new highly potent HMG-CoA reductase inhibitor
β Scribed by G. Wess; K. Kesseler; E. Baader; W. Bartmann; G. Beck; A. Bergmann; H. Jendralla; K. Bock; O. Holzstein; H. Kleine; M. Schnierer
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 208 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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The synthesis of a new fluoro-substituted 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor 2 in high optical purity via addition of the chiral enolate 12 to fluoro aldehyde 82 is described.
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