Stereoselective synthesis of (25S)-25-hydroxyvitamin D3 26,23-lactone
โ Scribed by Sachiko Yamada; Keiko Nakayama; Hiroaki Takayama
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- French
- Weight
- 453 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Two new fluorinated 25-hydroxyvitamin D3 analogs, 26,26,26-trifluoro-25-hydroxy (2) and 27-nor-26,26,26-trifluoro-25-hydroxyvitamin D3 (i), were prepared from 24-phenylsulfonyl 25,26,27-triorcholest-5-en-3B-yl tetrahydropyranyl ether (A). It is well known that vitamin D3 must be sequentially hydroxy
25l?)-25,26-Dihydroxy-23-oxovitamin D3 was synthesized efficiently and stereoselectively, and it was converted enzymatically to (25R\_)-lcr,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of la,25\_dihydroxyvitamin D3. The spectral and chemical properties of (25R&25,26-dihydroxy-23-oxovitam
In addition to the la-hydroxy group essential for eliciting biological activity, vitamin D3 metabolites bear the hydroxyl function in side chain at C-24, C-25 and/or C-26.2 Among those, the absolute configuration at C-24 in the 24-hydroxylated metabolites, 24,25\_dihydroxyvitamin D33 and 1,24,25\_tr