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Stereoselective synthesis of (25R)-25,26-dihydroxy-23-oxovitamin D3 and its enzymatic conversion to (25R)-1α,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of vitamin D3

✍ Scribed by Sachiko Yamada; Keiko Nakayama; Hiroaki Takayama; Toshimasa Shinki; Tatsuo Suda

Publisher: Elsevier Science
Year: 1984
Tongue: French
Weight: 256 KB
Volume: 25
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)91020-2

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✦ Synopsis

25l?)-25,26-Dihydroxy-23-oxovitamin D3 was synthesized efficiently and stereoselectively, and it was converted enzymatically to (25R_)-lcr,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of la,25_dihydroxyvitamin D3. The spectral and chemical properties of (25R&25,26-dihydroxy-23-oxovitamin D3 and its la-hydroxylated derivative disagree with those reported for the isolated metabolite.

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