25l?)-25,26-Dihydroxy-23-oxovitamin D3 was synthesized efficiently and stereoselectively, and it was converted enzymatically to (25R\_)-lcr,25,26-trihydroxy-23-oxovitamin D3, a putative metabolite of la,25\_dihydroxyvitamin D3. The spectral and chemical properties of (25R&25,26-dihydroxy-23-oxovitam
An efficient synthesis of (22E,25R)-1α,25,26-trihydroxy-Δ22-Vitamin D3
✍ Scribed by Masami Okabe; Ruen-Chu Sun
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- French
- Weight
- 261 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0040-4039
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An efficient synthesis of the title compound is reported based on C-l functionalization of the triazoline Diels-Alder adduct of 25-OH previtamin D3 (2). lu,25-Dihydroxy vitamin D3 (la) is considered as the most important and active natural metabolite of vitamin D 1 3 -Recently we have described a no
## Abstract Synthesis of two tritiated 1α,25‐dihydroxy‐22‐oxavitamin D~3~ (OCT), [26‐^3^H~3~]OCT (3) and [2β‐^3^H]OCT (4), is described. [26‐^3^H~3~]OCT (3) was prepared by tritiation at the side chain with tritiated methylmagnesium iodide and [2β‐^3^H]OCT (4) was labeled at the A‐ring by tritiatio
Synthesis of a C-24-epimeric mixture of 25-hydroxy-[26,27-3H]vitamin D2 and a C-24-epimeric mixture of 1,25-dihydroxy-[26,27-'HIvitamin D2 by the Grignard reaction of the corresponding 25-keto-27-nor-vitamin D2 and lo-acetoxy-25keto-27-nor-vitamin D3 with tritiated methyl magnesium bromide is descri
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v