Synthesis of 23,23-difluoro-25-hydroxyvitamin D3
β Scribed by Takeo Taguchi; Satoshi Mitsuhashi; Akiko Yamanouchi; Yoshiro Kobayashi; Hiroshi Sai; Nobuo Ikekawa
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 211 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
From cholenic acid 24,24-difluoro-25-hydroxyvitamin D3 and 245fluoro-25-hydroxyvitamin D3 were prepared.
Extraction, lipid-reduction, and chromatographic methods suitable for the resolution and subsequent quantitation of vitamin D2, vitamin D3, 25-hydroxyvitamin D2, and 25-hydroxy-vitamin D3 from human milk are described. This procedure utilizes a methanol:methylene chloride extraction, precipitation o
A synthesis of 25hydroxy [23,24JH]vitamin D3 leading to a radiochemically pure product with a specific activity of 78 Wmmol is described. The structure of the product was confirmed by comparison with unlabeled material and its biological activity was established by in vitro conversion to la,25dihydr