## Abstract The preparation of [^3^H]Sch 727965 from unlabeled compound and tritiated water was base catalyzed. Diethyl [^13^C~3~]malonate was used to prepare [^13^C~3~]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [^14^C]Sch 727965 was prepared in five steps from diethyl [2
Some IT and data processing applications for 2H,3H,11C,13C and 14C-labelling
โ Scribed by William J. S. Lockley; Kostas Sfyrakis; Brendan J. Howlin; John R. Jones; David J. Wilkinson
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 98 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2135
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## Abstract ^2^H and ^3^H labelled Sch 40120 were prepared by Pt catalysed exchange with isotopic water. D7โSch 40120 was obtained in two exchanges in 53% yield and ^3^HโSch 40120 was prepared by a single exchange at a specific activity of 19.8 Ci/mmole. ^14^CโSch 40120 was prepared in 4 steps from
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H and 13C N M R data for palitantine and three derivatives, iodopalitantine, palitantol and diacetate palitantine, are reported. Spectral assignment was carried out on the basis of two-dimensional ' H,' H and heteronuclear ' H,' 3C correlation experiments. ## KEYWORDS ' H NMR; 13C NMR; palitantine