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Somatic mutations in the neurofibromatosis 1 gene in human tumors

โœ Scribed by Ying Li; Gideon Bollag; Robin Clark; Jeff Stevens; Leah Conroy; Dan Fults; Ken Ward; Eitan Friedman; Wade Samowitz; Margaret Robertson; Paige Bradley; Frank McCormick; Ray White; Richard Cawthon


Book ID
119064229
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
856 KB
Volume
69
Category
Article
ISSN
0092-8674

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## Communicated by Haig H. Kazazian One of the main features of neurofibromatosis type 1 (NF1) is benign neurofibromas, 10-20% of which become transformed into malignant peripheral nerve sheath tumors (MPNSTs). The molecular basis of NF1 tumorigenesis is, however, still unclear. Ninety-one tumors