Somatic mutations in the neurofibromatosis type 2 gene in sporadic meningiomas
β Scribed by Laura Papi; Lucia Rosaria Vitis; Francesca Vitelli; Enrico Montali; Umberto Bigozzi; Franco Ammannati; Pasquale Mennonna
- Publisher
- Springer
- Year
- 1995
- Tongue
- English
- Weight
- 574 KB
- Volume
- 95
- Category
- Article
- ISSN
- 0340-6717
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Communicated by Marc S. Greenblatt Constitutional heterozygous inactivating mutations in the neurofibromatosis 2 (NF2) tumor suppressor gene cause the autosomal dominant disease NF2, and biallelic inactivating somatic NF2 mutations are found in a high proportion of unilateral sporadic vestibular sch
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## Abstract The __NF2__ gene is a putative tumorβsuppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumorβsusceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide