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Somatic mutations in the neurofibromatosis type 2 gene in sporadic meningiomas

✍ Scribed by Laura Papi; Lucia Rosaria Vitis; Francesca Vitelli; Enrico Montali; Umberto Bigozzi; Franco Ammannati; Pasquale Mennonna


Publisher
Springer
Year
1995
Tongue
English
Weight
574 KB
Volume
95
Category
Article
ISSN
0340-6717

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## Abstract The __NF2__ gene is a putative tumor‐suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor‐susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the __NF2__ gene on chromosome 22 allows the ide