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Segmental neurofibromatosis is caused by somatic mutation of the neurofibromatosis type 1 (NF1) gene

✍ Scribed by Tinschert, Sigrid; Naumann, Ilka; Stegmann, Elisabeth; Buske, Annegret; Kaufmann, Dieter; Thiel, Gundula; Jenne, Dieter E

Book ID
110024987
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
163 KB
Volume
8
Category
Article
ISSN
1018-4813

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## Communicated by Haig H. Kazazian One of the main features of neurofibromatosis type 1 (NF1) is benign neurofibromas, 10-20% of which become transformed into malignant peripheral nerve sheath tumors (MPNSTs). The molecular basis of NF1 tumorigenesis is, however, still unclear. Ninety-one tumors