Solid-Phase Synthesis of Substituted Tetramic Acids
β Scribed by Matthews, Jay; Rivero, Ralph A.
- Book ID
- 126257848
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 42 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Acyl tetramic acids have been prepared by directed metallation at C-3 of the 4-g-methyl ethers of pyrrolidine-2,4diones, reaction of the vinyl-lithium derivative with aldehydes, and oxidation and hydrolysis of the adducts.
A solid-phase synthesis of benzimidazoles, substituted on the aromatic ring by a variety of groups or atoms, is described. Intermediate 3, derived from the acylation of a resin-bound secondary amine with Fmoc-glycine, was elaborated via nucleophilic displacement with substituted o-halonitroarenes to
Nitrone ylids prepared from a-amino aldehyde derivatives undergo 1,3-dipolar cyclocondensation reactions to give enantiopure C-4 branched N-hydroxy proline esters. The different functional groups can be manipulated to provide diversely substituted N-hydroxypyrrolidine dicarboxylic acids. The reactio