✦ LIBER ✦

Solution- and solid-phase asymmetric synthesis of substituted N-hydroxypyrrolidine dicarboxylic acids

✍ Scribed by Stephen Hanessian; Malken Bayrakdarian

Book ID: 104252445
Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 309 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02288-8

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✦ Synopsis

Nitrone ylids prepared from a-amino aldehyde derivatives undergo 1,3-dipolar cyclocondensation reactions to give enantiopure C-4 branched N-hydroxy proline esters. The different functional groups can be manipulated to provide diversely substituted N-hydroxypyrrolidine dicarboxylic acids. The reaction can be adapted to solid-phase synthesis.

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