Solid phase synthesis of peptides containing novel amino acids, substituted 3-benzimidazolealanines
✍ Scribed by Małgorzata Koprowska-Ratajska; Alicja Kluczyk; Piotr Stefanowicz; Hubert Bartosz-Bechowski; Zbigniew Szewczuk
- Book ID
- 106221628
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 282 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0939-4451
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Barton esters were prepared starting from different carboxylic acids loaded on a Wang resin. Light induced fragmentation occurred giving a radical that reacted with CBrCl 3 to give the corresponding bromides, whereas conjugate addition to electron-poor alkenes proved to be less synthetically useful.
## Abstract This work reports on the synthesis of a wide range of ferrocenyl‐substituted amino acids and peptides in excellent yield. Conjugation is established via copper‐catalyzed 1,3‐dipolar cycloaddition. Two complementary strategies were employed for conjugation, one involving cycloaddition of