Directed metallation of tetramic acids: a new synthesis of 3-acyl tetramic acids
โ Scribed by Raymond C.F. Jones; Graeme E. Peterson
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- French
- Weight
- 198 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Acyl tetramic acids have been prepared by directed metallation at C-3 of the 4-g-methyl ethers of pyrrolidine-2,4diones, reaction of the vinyl-lithium derivative with aldehydes, and oxidation and hydrolysis of the adducts.
๐ SIMILAR VOLUMES
Boron difluoride complexes of 3-acyl tetramic acids have been isolated from acylation of pyrrolidine-2,4-diones with acid chlorides and boron trifluoride-etherate, or prepared from 3-acyl tetramic acids.
Acetoacetic ester is converted can be hydrolyzed to give tetramic acids. The 2,4-pyrrolidinedione nucleus (4)
The quaternary ammonium enolates of 5-substituted pyrrolidine-2,4-diones undergo isomerisation to the exocyclic A5r6-isomers during g-acylation. The group of 3-acyl tetramic acids of general structure (1) are microbial