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Solid-phase synthesis of tetramic acids

✍ Scribed by Bheemashankar A. Kulkarni; A. Ganesan


Book ID
108386773
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
200 KB
Volume
39
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Directed metallation of tetramic acids:
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Acyl tetramic acids have been prepared by directed metallation at C-3 of the 4-g-methyl ethers of pyrrolidine-2,4diones, reaction of the vinyl-lithium derivative with aldehydes, and oxidation and hydrolysis of the adducts.

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The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr

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Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA

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✍ Hogendorf, Wouter F. J.; Meeuwenoord, Nico; Overkleeft, Herman S.; Filippov, Dmi πŸ“‚ Article πŸ“… 2011 πŸ› Royal Society of Chemistry 🌐 English βš– 731 KB